Peptide Stacks
Popular peptide combinations with evidence summaries, synergy mechanisms, and research citations.
Many peptides are used in combination to target complementary pathways — from the BPC-157 + TB-500 recovery stack to growth hormone secretagogue pairings and GLP-1 formulations with nutrient support. Each stack page explains why the peptides are combined, the proposed synergy mechanism, what the evidence actually shows, and important considerations for clinical use.
Weight Loss
GLP-1 agonist combinations and amylin/incretin co-administrations targeting body weight and metabolic health.
Semaglutide + B12 (Compounded Semaglutide)
The most commonly prescribed compounded semaglutide formulation for weight loss. Pairs GLP-1 therapy with vitamin B12 to address nutrient absorption concerns and support energy during caloric restriction. Often includes glycine.
CagriSema / CagriTriz / CagriReta (Cagrilintide + GLP-1 Agonist)
A family of weekly injectable obesity stacks that pair the long-acting amylin analog cagrilintide with a GLP-1 receptor agonist — semaglutide (CagriSema), tirzepatide (CagriTriz), or retatrutide (CagriReta). Only CagriSema has completed pivotal clinical trials; the other two are conceptual compounded or investigational combinations.
Tirzepatide + B12 / Glycine (Compounded Tirzepatide)
Compounded tirzepatide mixed with vitamin B12 (cyanocobalamin), sometimes with glycine, niacinamide, or B6 added. The tirzepatide has some of the strongest evidence in obesity medicine (the SURMOUNT trials). The additives have no outcome evidence. They mostly exist to argue the product is not 'essentially a copy' of Zepbound or Mounjaro now that FDA has ended the tirzepatide shortage. This page covers what B12 adds, why the vial is pink, and where FDA enforcement stands in 2026.
Retatrutide + Tesamorelin
A gray-market pairing of Lilly's unapproved triple agonist retatrutide (or, more often, tirzepatide) with tesamorelin, the FDA-approved GHRH analog for HIV-associated belly fat. The pitch is extra visceral-fat loss and protected muscle. No trial has tested it. Growth hormone works against the incretin's blood-sugar benefit, GLP-1-class drugs already cut visceral fat on their own, and 'tesamorelin preserves lean mass on a GLP-1' is untested.
Healing & Recovery
Tissue repair, wound healing, and post-injury stacks built around BPC-157, TB-500, GHK-Cu, and KPV.
Wolverine Peptide Stack (BPC-157 + TB-500)
The Wolverine Stack is the most popular peptide recovery combination — BPC-157 for localized tissue repair paired with TB-500 for systemic healing, cell migration, and anti-inflammatory support.
GLOW Peptide Stack (BPC-157 + TB-500 + GHK-Cu)
GLOW is a popular pre-mixed compounded peptide blend combining BPC-157 tissue repair, TB-500 cell migration, and GHK-Cu collagen remodeling in a single 70 mg vial. Also covers the two-peptide BPC-157 + GHK-Cu pairing for practitioners sourcing vials separately.
KLOW Peptide Stack (BPC-157 + TB-500 + GHK-Cu + KPV)
KLOW is a pre-mixed four-peptide compounded blend combining BPC-157 and TB-500 systemic repair, GHK-Cu collagen remodeling, and KPV anti-inflammatory coverage in a single 80 mg vial. It extends the popular GLOW formulation with an explicit anti-inflammatory layer.
Growth Hormone
GHRH-analog plus ghrelin-mimetic pairings designed to amplify the body's natural pulsatile GH release.
CJC-1295 + Ipamorelin (The GH Secretagogue Stack)
The classic growth hormone secretagogue stack — often called the GH stack or sleep stack. Combines GHRH signaling (CJC-1295) with selective ghrelin receptor activation (ipamorelin) to amplify the body's natural nighttime growth hormone pulse.
Tesamorelin + Ipamorelin (FDA-Backed GHRH Analog + Selective Ghrelin-Mimetic)
A growth hormone secretagogue stack that pairs the only FDA-approved GHRH analog (tesamorelin) with the cleanest ghrelin-receptor trigger (ipamorelin). Delivers the same GHRH + ghrelin dual-pathway synergy as CJC-1295 + ipamorelin, with tesamorelin's Phase III evidence base standing in for the compounded GHRH leg.
Sermorelin + Glycine (The Sleep & GH Stack)
Pairs sermorelin's growth hormone-releasing activity with glycine's sleep-enhancing and metabolic benefits for optimized nighttime GH release and recovery.
Sermorelin + Ipamorelin (Compounded GH Blend)
The default growth hormone blend at many anti-aging, men's health, and telehealth clinics. It pairs sermorelin, a GHRH fragment once FDA-approved as Geref, with ipamorelin, the most selective ghrelin-receptor agonist. The GHRH-plus-ghrelin-mimetic synergy is real human physiology, but no trial has tested this pair, and the two halves have very different US compounding status.
Longevity & Mitochondrial
Concept stacks targeting NAD+ pool, sirtuins, AMPK, and mitochondrial-derived peptide signaling.
NAD+ / MOTS-c / 5-Amino-1MQ (Mitochondrial Longevity Stack)
A concept stack popular in longevity peptide circles that pairs an NAD+ precursor (NMN or NR), the mitochondrial-derived peptide MOTS-c, and the NNMT inhibitor 5-Amino-1MQ to target mitochondrial energetics, NAD+ pool preservation, and AMPK-driven exercise-mimetic metabolism. The biochemical rationale is genuinely synergistic, but no controlled human trial has tested the combination — treat this as a mechanistic hypothesis with three components at very different evidence tiers.
MOTS-c + SS-31 (Mitochondrial Stack)
A two-peptide mitochondrial stack that pairs MOTS-c with SS-31 (elamipretide). MOTS-c is a signaling peptide encoded in mitochondrial DNA that activates AMPK and relays signals to the nucleus. SS-31 binds cardiolipin and stabilizes the inner mitochondrial membrane, where ATP is made. The two mechanisms genuinely complement each other: one changes how the cell adapts, the other protects the machinery doing the work. But no study has tested the combination. MOTS-c has almost no human interventional data, and SS-31's only approval is for an ultra-rare disease, after several failed trials in other conditions.
Epitalon + Pinealon (Khavinson Bioregulator Stack)
A course-based longevity stack from Vladimir Khavinson's peptide bioregulator program in St. Petersburg. It pairs Epitalon (AEDG, the synthetic "pineal" tetrapeptide) with Pinealon (EDR, a tripeptide studied mainly for neuroprotection) and often adds Thymalin, a calf-thymus peptide extract. The evidence is weak. Nearly all of it comes from a single research lineage, most is preclinical, and the one long-term human mortality study used gland extracts (Epithalamin and Thymalin), not the synthetic peptides sold today. No trial has tested the stack itself.
Cognitive & Mood
Neuropeptide combinations for focus, anxiety, and stress resilience.
Sexual Wellness
Stacks pairing central arousal signaling with bonding and intimacy support.
Immune & Inflammation
Combinations targeting systemic immune modulation alongside local anti-inflammatory action.
Thymosin Alpha-1 + KPV (The Immune & Gut Stack)
Pairs systemic immune modulation (Thymosin Alpha-1) with targeted gut anti-inflammatory action (KPV) for comprehensive immune and gastrointestinal support.
BPC-157 + KPV (Oral Gut Stack)
An oral, gut-focused pairing of BPC-157, a gastric pentadecapeptide studied for mucosal protection and repair, with KPV, an anti-inflammatory tripeptide from alpha-MSH that intestinal cells absorb through the PepT1 transporter. The idea is to calm intestinal inflammation with one and support repair of the gut lining with the other, usually as capsules. The evidence is entirely preclinical. Both peptides reduce colitis in rodents, but neither has a published human trial for gut disease, oral bioavailability in humans has not been measured for either, and the combination has never been tested.